Ayurveda is a bygone science of life. It has its own basic concepts like Dosha, Dhatu, Mala, Agni, Ama, etc. Ama plays a major role as a causing factor of so many diseases. The knowledge about causative factors of disease helps to decide a better line of treatment. Due to Agnimandya digestion of food doesn’t takes place properly and this further leads to the production of Ama. Therefore, Agnimandya leads to the production of Ama & vice versa. Basically, Ama is considered as Apakva Ahara Rasa which is produced due to Mandagni. Further, it circulates all over the body through Srotas causing Srotovaigunya, & plays a major role in the manifestation of various diseases. The Dosha, Dhatu, and Mala depraved by Ama are known as Sama Dosha, Sama Dushya, and Saama Mala. If the line of treatment for the disease is planned by understanding the concept of Sama and Nirama, it would give a better result. In this review article, the concept of Ama is described from different Ayurveda Samhita’s and texts. Ayurveda attributes the cause of any disease to an imbalance in one or all of the Dosha and for successful treatment of a particular disease Vaidya has to determine, whether the imbalanced Dosha is Saama or Nirama. In this review, the article covers all points related to Ama from Samhita & available latest literature from the internet. Keywords: Ama, Saama, Nirama, Agni, Agnimandya, Apakva Ahara Rasa.
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